Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiosensitivity of lymphoblastoid cell lines with a heterozygous BRCA1 mutation is not detected by the comet assay and pulsed field gel electrophoresis.

Mutagenesis - 1 Mar 2005

Trenz Kristina, Schütz Petra, Speit Günter

Abstract excerpt

Lymphoblastoid cell lines (LCL) with a heterozygous mutation in the breast cancer susceptibility gene BRCA1 have been repeatedly used to elucidate the biological consequences of such a mutation with respect to radiation sensitivity and DNA repair deficiency. Our previous results indicated that LCL with a BRCA1 mutation do not generally show the same chromosomal mutagen sensitivity in the micronucleus test as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comet Assay
Share to Electrophoresis, Gel, Pulsed-Field

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gamma Rays

Share to Genes, BRCA1

Share to Hydrogen-Ion Concentration

Share to Lymphocytes

Share to Mutagenicity Tests

Share to Radiation Tolerance

Source

Identifiers

PMID: 15784691
DOI: 10.1093/mutage/gei018

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiosensitivity of lymphoblastoid cell lines with a heterozygous BRCA1 mutation is not detected by the comet assay and pulsed field gel electrophoresis.PMID 15784691Read ↗

Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells.Semantic proximity Read ↗

Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation.Semantic proximity Read ↗

Radiosensitivity in breast cancer assessed by the Comet and micronucleus assaysSemantic proximity Read ↗

Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: Defective rejoining of radioinduced dna strand breaks in lymphocytes of breast cancer patientsSemantic proximity Read ↗

DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers.Semantic proximity Read ↗

Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families.Semantic proximity Read ↗

Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay.Semantic proximity Read ↗

Quantitative DNA damage and repair measurement with the yeast comet assay.Semantic proximity Read ↗

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair.Semantic proximity Read ↗

Radiation-Induced Apoptosis Measured in TK6 Human B Lymphoblast Cells Using the Comet AssaySemantic proximity Read ↗

DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.Semantic proximity Read ↗

Assessment of DNA Damage Induced by Broadband and Narrowband UVB in Cultured Lymphoblasts and Keratinocytes Using the Comet AssaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.