Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells.

Cytogenetics and cell genetics - 1 Jan 2000

Speit G, Trenz K, Schütz P, Bendix R, Dörk T

Abstract excerpt

Our previous results indicated a close relationship between the presence of a BRCA1 mutation in lymphocytes and hypersensitivity for the induction of micronuclei by gamma irradiation and hydrogen peroxide (H(2)O(2)). Comparative investigations with the comet assay (single-cell gel electrophoresis) suggested a normal rate of damage removal and pointed to a disturbed fidelity of DNA repair as a direct or indirect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia
Share to Caffeine
Share to Comet Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gamma Rays

Share to Hydrogen Peroxide

Share to Micronuclei, Chromosome-Defective

Share to Micronucleus Tests

Share to Mutagens

Source

Identifiers

PMID: 11173867
DOI: 10.1159/000056855

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells.PMID 11173867Read ↗

Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation.Semantic proximity Read ↗

Radiosensitivity of lymphoblastoid cell lines with a heterozygous BRCA1 mutation is not detected by the comet assay and pulsed field gel electrophoresis.Semantic proximity Read ↗

Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families.Semantic proximity Read ↗

Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay.Semantic proximity Read ↗

Chromosomal mutagen sensitivity associated with mutations in BRCA genes.Semantic proximity Read ↗

Quantitative DNA damage and repair measurement with the yeast comet assay.Semantic proximity Read ↗

DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests.Semantic proximity Read ↗

Assessment of genotoxic effects related to chronic low level exposure to ionizing radiation using biomarkers for DNA damage and repair.Semantic proximity Read ↗

Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment.Semantic proximity Read ↗

Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers.Semantic proximity Read ↗

Radiosensitivity in breast cancer assessed by the Comet and micronucleus assaysSemantic proximity Read ↗

Relationship between Caffeine and Levels of DNA Repair and Oxidative Stress in Women with and without a BRCA1 Mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.