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Article

DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers.

British journal of cancer - 15 Jan 2007

Kotsopoulos J, Chen Z, Vallis K A, Poll A, Ainsworth P, Narod S A

Abstract excerpt

The BRCA1 gene product helps to maintain genomic integrity through its participation in the cellular response to DNA damage: specifically, the repair of double-stranded DNA breaks. An impaired cellular response to DNA damage is a plausible mechanism whereby BRCA1 mutation carriers are at increased risk of breast cancer. Hence, an individual's capacity to repair DNA may serve as a useful biomarker of breast cancer...

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Identifiers

PMID: 17213827
DOI: 10.1038/sj.bjc.6603528
PMCID: PMC2360222

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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