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Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays

14 Mar 2006

Abstract excerpt

Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from cancer patients (n=9) with an adverse early skin reaction to radiotherapy (RT) served as references....

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PMID: 16538220
DOI: 10.1038/sj.bjc.6603005

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