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Article

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair.

Mutagenesis - 1 Mar 2006

Langie Sabine A S, Knaapen Ad M, Brauers Karen J J, van Berlo Damien, van Schooten Frederik-Jan, Godschalk Roger W L

Abstract excerpt

There is an increasing need for simple and reliable approaches to phenotypically assess DNA repair capacities. Therefore, a modification of the alkaline comet assay was developed to determine the ability of human lymphocyte extracts to perform the initial steps of the nucleotide excision repair (NER) process, i.e. damage recognition and incision. Gel-embedded nucleoids from A549 cells, pre-exposed to 1 microM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16556641
DOI: 10.1093/mutage/gel013

Genes

XPA
XPC

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