Article
T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity.
PLoS medicine - 1 Mar 2005
Verhoef Adrienne, Alexander Clare, Kay A Barry, Larché Mark
Abstract excerpt
BACKGROUND: Synthetic peptides, representing CD4(+) T cell epitopes, derived from the primary sequence of allergen molecules have been used to down-regulate allergic inflammation in sensitised individuals. Treatment of allergic diseases with peptides may offer substantial advantages over treatment with native allergen molecules because of the reduced potential for cross-linking IgE bound to the surface of mast...
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