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Article

Phenotypic and functional characterization of freshly isolated and expanded canine regulatory T cells.

Experimental animals - 1 Jan 2011

Knueppel Anne, Lange Sandra, Sekora Anett, Altmann Simone, Freund Mathias, Junghanss Christian

Abstract excerpt

Regulatory T cells (T(reg)) are CD4(+) T lymphocytes with constitutive expression of CD25 and FOXP3, as well as the ability to modulate cellular immune responses. In this study, the phenotypic characteristics, function and feasibility of enrichment and expansion of canine T(reg) were examined. Canine peripheral blood mononuclear cells were isolated and enriched by labelling of CD25, and expansion of T(reg) was...

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Identifiers

PMID: 22041284
DOI: 10.1538/expanim.60.471

Genes

FOXP3

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