Article
Selective COX-2 Inhibition Exerts No Negative Effects on Peripheral Blood Lymphocytes in Allergic Asthmatics.
International archives of allergy and immunology - 1 Jan 2016
Gafvelin Guro, Grundström Jeanette, Edin Grimheden Maria, Sánchez Vidaurre Sara, Daham Kameran, Dahlén Sven-Erik, Dahlén Barbro, van Hage Marianne
Abstract excerpt
BACKGROUND: Selective inhibition of cyclooxygenase-2 (COX-2) reduces the production of prostaglandin E2 (PGE2), which can have both pro- and anti-inflammatory effects on allergic inflammation. Moreover, in vitro PGE2 has been shown to affect inflammation through the modulation of lymphocyte responses. METHODS: Sixteen subjects with mild allergic asthma were recruited to a two-period cross-over study: one...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.