Article
Myelin deficiency in female rats due to a mutation in the PLP gene.
Journal of the neurological sciences - 1 Jan 1992
Koeppen A H, Csiza C K, Willey A M, Rønne M, Barron K D, Dearborn R E, Hurwitz C G
Abstract excerpt
Myelin deficiency (md) in female rats due to a mutation in the X-linked proteolipid protein (PLP) gene is caused by X-chromosome monosomy. Cytogenetic analysis revealed a single X karyotype [41,X(md/0)]. An immunocytochemical, electron microscopic, and biochemical study was performed on male and...
Topics
- Animals
- Brain
- Chromatin
- Demyelinating Diseases
- Electrophoresis, Polyacrylamide Gel
- Female
- Immunohistochemistry
- Karyotyping
- Male
- Microscopy, Electron
- Monosomy
- Mutation