Article
Rumpshaker: an X-linked mutation affecting CNS myelination. A study of the female heterozygote.
Neuropathology and applied neurobiology - 1 Aug 1991
Fanarraga M L, Griffiths I R, McCulloch M C, Barrie J A, Cattanach B M, Brophy P J, Kennedy P G
Abstract excerpt
This study examines the myelin deficits found in the spinal cord and optic nerves of female mice heterozygotes for rumpshaker (rsh), an X-linked mutation causing hypomyelination. No clinical abnormalities were detected but morphological changes were evident, particularly in the spinal cord, which...
Topics
- Animals
- Central Nervous System
- Central Nervous System Diseases
- Female
- Genetic Linkage
- Heterozygote
- Immunohistochemistry
- Male
- Mice
- Mutation
- Myelin Sheath
- Nucleic Acid Hybridization
- Phenotype
- X Chromosome