Article
Rumpshaker: an X-linked mutation affecting CNS myelination. A study of the female heterozygote.
Neuropathology and applied neurobiology - 1 Aug 1991
Fanarraga M L, Griffiths I R, McCulloch M C, Barrie J A, Cattanach B M, Brophy P J, Kennedy P G
Abstract excerpt
This study examines the myelin deficits found in the spinal cord and optic nerves of female mice heterozygotes for rumpshaker (rsh), an X-linked mutation causing hypomyelination. No clinical abnormalities were detected but morphological changes were evident, particularly in the spinal cord, which showed no evidence of resolving with age. In the spinal cord, scattered hypomyelinated axons, occasionally grouped in...
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