Article
Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis.
Pancreas - 1 Apr 2005
Tukiainen Eija, Kylänpää Marja-Leena, Kemppainen Esko, Nevanlinna Heli, Paju Annukka, Repo Heikki, Stenman Ulf-Håkan, Puolakkainen Pauli
Abstract excerpt
OBJECTIVES: Mutations in the secretory trypsin inhibitor (SPINK1) gene have been found to be associated with hereditary and chronic pancreatitis. There are no previous reports on SPINK1 mutations in patients with acute pancreatitis (AP). METHODS: The study population consists of 371 patients with AP, of which 207 patients had mild and 164 had a severe form of the disease. The etiologies of AP were identified....
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