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Article

The SPINK1 N34S variant is associated with acute pancreatitis.

European journal of gastroenterology & hepatology - 1 Aug 2008

O'Reilly Derek A, Witt Heiko, Rahman Sakhawat H, Schulz Hans-Ulrich, Sargen Kevin, Kage Andreas, Cartmell Mark T, Landt Olfert, Larvin Michael, Demaine Andrew G, McMahon Michael J, Becker Michael, Kingsnorth Andrew N

Abstract excerpt

OBJECTIVE: Acute pancreatitis (AP) is a disease whose pathogenesis remains largely obscure. Genetic research has focussed attention upon the role of the pancreatic protease/protease inhibitor system. The aim of this study was to investigate the prevalence of genetic variants of the trypsin inhibitor, SPINK1, in acute pancreatitis. METHODS: We genotyped 468 patients with AP and 1117 healthy controls for SPINK1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carrier Proteins

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Share to Polymorphism, Single-Stranded Conformational

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 18617776
DOI: 10.1097/MEG.0b013e3282f5728c

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SPINK1 N34S variant is associated with acute pancreatitis.PMID 18617776Read ↗

Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis.Semantic proximity Read ↗

Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.Semantic proximity Read ↗

Presence of SPINK-1 variant alters the course of chronic pancreatitis.Semantic proximity Read ↗

Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis?Semantic proximity Read ↗

SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.Semantic proximity Read ↗

Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis.Semantic proximity Read ↗

Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis.Semantic proximity Read ↗

Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitisSemantic proximity Read ↗

SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event.Semantic proximity Read ↗

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis.Semantic proximity Read ↗

The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.Semantic proximity Read ↗

Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.Semantic proximity Read ↗

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