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Article

Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States.

Digestive diseases and sciences - 1 Jun 2003

Schneider Alexander, Pfützer Roland H, Barmada M Michael, Slivka Adam, Martin John, Whitcomb David C

Abstract excerpt

Mutations in the SPINK1 gene (e.g. N34S) have been reported in patients with idiopathic, familial, tropical, and alcoholic pancreatitis. The prevalence of SPINK1 N34S differs between different patient populations, and its contribution to the risk and the severity of alcoholic chronic pancreatitis...

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Source

Identifiers

PMID: 12822871
DOI: 10.1023/a:1023768829772

Genes

SPINK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12822871-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States.PMID 12822871Read ↗

The N34S mutation of the SPINK1 gene and alcoholic chronic pancreatitis.Semantic proximity Read ↗

Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis.Semantic proximity Read ↗

Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update.Semantic proximity Read ↗

Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis.Semantic proximity Read ↗

Investigation of the SPINK1 N34S mutation in Romanian patients with alcoholic chronic pancreatitis. A clinical analysis based on the criteria of the M-ANNHEIM classification.Semantic proximity Read ↗

Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.Semantic proximity Read ↗

Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis.Semantic proximity Read ↗

Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis.Semantic proximity Read ↗

The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.Semantic proximity Read ↗

SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.Semantic proximity Read ↗

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis.Semantic proximity Read ↗

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer.Semantic proximity Read ↗

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