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Article

SPINK1 gene mutations and pancreatitis in Japan.

Journal of gastroenterology and hepatology - 1 Oct 2006

Shimosegawa Tooru, Kume Kiyoshi, Masamune Atsushi

Abstract excerpt

SPINK1 can inhibit up to 20% of trypsin activity, and may constitute one major mechanism to protect the pancreas from autodigestion. In 2000, Witt et al. first recognized the association between mutations in the SPINK1 gene and chronic pancreatitis (CP), but the significance of SPINK1 gene mutation in pancreatitis and its relation to alcohol consumption remains unclear in Japan. The aim of the present paper was...

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Topics

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Share to Carrier Proteins
Share to DNA Mutational Analysis
Share to SPINK1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Pancreatitis

Share to Polymorphism, Genetic

Share to Trypsin Inhibitor, Kazal Pancreatic

Source

Identifiers

PMID: 16958672
DOI: 10.1111/j.1440-1746.2006.04594.x

Genes

SPINK1
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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