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Article

Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.

Gut - 1 May 2002

Drenth J P H, te Morsche R, Jansen J B M J

Abstract excerpt

BACKGROUND: Although chronic pancreatitis is associated with risk factors such as alcoholism, hyperparathyroidism, and hypertriglyceridaemia, little is known of the actual aetiology of the disease. It is thought that inappropriate activation of trypsinogen causes pancreatitis, and indeed in cases of hereditary pancreatitis mutations of cationic trypsinogen (PRSS1) have been described. As serine protease inhibitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Trypsin Inhibitor, Kazal Pancreatic

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Source

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Identifiers

PMID: 11950817
DOI: 10.1136/gut.50.5.687
PMCID: PMC1773221

Genes

SPINK1
PRSS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.PMID 11950817Read ↗

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