Article
Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2005
Castino Roberta, Davies Janet, Beaucourt Stephanie, Isidoro Ciro, Murphy David
Abstract excerpt
Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is a progressive, inherited neurodegenerative disorder that presents as polydipsia and polyuria as a consequence of a loss of secretion of the antidiuretic hormone vasopressin (VP) from posterior pituitary nerve terminals. VP gene mutations cause adFNDI. Rats expressing an adFNDI VP transgene (Cys67stop) show a neuronal pathology...
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