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Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS

6 Aug 2015

Abstract excerpt

Autophagy plays a major role in the elimination of cellular waste components, the renewal of intracellular proteins and the prevention of the build-up of redundant or defective material. It is fundamental for the maintenance of homeostasis and especially important in post-mitotic neuronal cells, which, without competent autophagy, accumulate protein aggregates and degenerate. Many neurodegenerative diseases are...

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PMID: 26287246
DOI: 10.3390/cells4030354

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