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Autophagy is induced and supports virus replication in Enterovirus A71-infected human primary neuronal cells

17 Sept 2020

Abstract excerpt

Enterovirus A71 (EV-A71), which belongs to the family Picornaviridae, can invade the central nervous system (CNS) and cause severe CNS complications or death. The EV-A71 antigen has been detected in the neurons in the brains of humans who died from EV-A71 infection. However, the effect of EV-A71 infection on human neuronal cells remains poorly understood. Human neural stem cells (NSCs) and IMR-32 neuroblastoma...

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PMID: 32943650
DOI: 10.1038/s41598-020-71970-3

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