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Article

Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia.

Nature genetics - 1 Apr 2005

Sebastiani Paola, Ramoni Marco F, Nolan Vikki, Baldwin Clinton T, Steinberg Martin H

Abstract excerpt

Sickle cell anemia (SCA) is a paradigmatic single gene disorder caused by homozygosity with respect to a unique mutation at the beta-globin locus. SCA is phenotypically complex, with different clinical courses ranging from early childhood mortality to a virtually unrecognized condition. Overt stroke is a severe complication affecting 6-8% of individuals with SCA. Modifier genes might interact to determine the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15778708
DOI: 10.1038/ng1533
PMCID: PMC2896308

Genes

SELP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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