Article
Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E.
Circulation. Genomic and precision medicine - 1 Oct 2020
Brewin John N, Smith Alexander E, Cook Riley, Tewari Sanjay, Brent Julie, Wilkinson Sarah, Brousse Valentine, Inusa Baba, Menzel Stephan, Rees David C
Abstract excerpt
BACKGROUND: Ischemic stroke is a devastating complication affecting children with sickle cell anemia. Genetic factors are likely to be important in determining the risk of stroke but are poorly defined. METHODS: We have studied a cohort of 19 children who had an overt ischemic stroke before 4 years of age. We predicted genetic determinants of stroke would be more prominent in this group. We performed whole exome...
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