Article
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Archives of medical research - 1 Jan 2000
Kocabaş Neslihan Aygün, Sardaş Semra, Sardas Semra, Karakaya Ali Esat, Karakaya Ali Estat
Abstract excerpt
BACKGROUND: Polymorphisms which are inherited alterations in the activity of cytochrome P450 1B1 (CYP1B1), catechol O-methyltransferase (COMT), manganese superoxide dismutase (MnSOD) hold the potential to define differences in estrogen metabolism and, thereby, possibly explain inter-individual differences in cancer susceptibility associated with estrogen-mediated carcinogenesis. METHODS: The CYP1B1 (L432V), COMT...
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