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Article

SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.

Molecular biology of the cell - 1 Dec 1997

Nislow C, Ray E, Pillus L

Abstract excerpt

The trithorax gene family contains members implicated in the control of transcription, development, chromosome structure, and human leukemia. A feature shared by some family members, and by other proteins that function in chromatin-mediated transcriptional regulation, is the presence of a 130- to 140-amino acid motif dubbed the SET or Tromo domain. Here we present analysis of SET1, a yeast member of the trithorax...

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Identifiers

PMID: 9398665
DOI: 10.1091/mbc.8.12.2421
PMCID: PMC25717

Genes

SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.PMID 9398665Read ↗

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.Semantic proximity Read ↗

Evolution and pleiotropy of TRITHORAX function in Arabidopsis.Semantic proximity Read ↗

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.Semantic proximity Read ↗

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains.Semantic proximity Read ↗

The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.Semantic proximity Read ↗

Esa1p is an essential histone acetyltransferase required for cell cycle progression.Semantic proximity Read ↗

A homeotic mutation in the trithorax SET domain impedes histone binding.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

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