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Article

Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant.

Digestion - 1 Jan 2005

Musch Annemarie, Rabe Christian, Paik Mignon-Denise, Berna Marc Jean, Schmitz Volker, Hoffmann Per, Nischalke Hans Dieter, Sauerbruch Tilman, Caselmann Wolfgang H

Abstract excerpt

BACKGROUND/AIMS: Hepatocellular carcinomas (HCC) often show resistance to the effects of transforming growth factor-beta (TGF-beta). This study focuses on molecular mechanisms of this resistance to explore ways to overcome it. METHODS: Transcription and protein expression of TGF-beta type I and type II receptors (TGF-betaRI/RII) were analyzed in clinical HCCs and the human hepatoma cell lines HuH-7 and HepG2....

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Transforming Growth Factor beta

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Source

Identifiers

PMID: 15775675
DOI: 10.1159/000084523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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