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Article

Altered expression of transforming growth factor-? ligands and receptors in primary and recurrent ovarian carcinoma

1 Feb 1999

Abstract excerpt

BACKGROUND: Resistance to the potent growth inhibitory effects of transforming growth factor-beta (TGF-beta) is a characteristic of many malignancies. TGF-beta insensitivity has been attributed to alterations in the number and function of the TGF-beta receptors as well as disturbances of downstream signal transduction. Paradoxically, increased levels of TGF-beta ligand have been demonstrated in several types of...

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PMID: 10091739
DOI: 10.1002/(sici)1097-0142(19990201)85:3<658::aid-cncr16>3.0.co;2-m

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