Article
Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase.
The Journal of biological chemistry - 3 Jun 2005
Merkel Martin, Loeffler Britta, Kluger Malte, Fabig Nathalie, Geppert Gesa, Pennacchio Len A, Laatsch Alexander, Heeren Joerg
Abstract excerpt
Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are inversely correlated with plasma triglycerides. To elucidate the mechanism by which apoAV influences plasma triglycerides, metabolic studies and in vitro assays resembling physiological conditions were performed. In human APOA5 transgenic...
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