Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Give me A5 for lipoprotein hydrolysis!

The Journal of clinical investigation - 1 Oct 2005

Merkel Martin, Heeren Joerg

Abstract excerpt

APOA5 is a newly identified apolipoprotein that plays a crucial role in the regulation of plasma triglyceride levels. In several human studies, common APOA5 single nucleotide polymorphisms have been strongly associated with elevated plasma triglyceride levels. In this issue of the JCI, Marçais et al. report that the rare Q139X mutation in APOA5 leads to severe hypertriglyceridemia by exerting a dominant-negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-V
Share to Apolipoproteins
Share to Apolipoproteins A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Lipoprotein Lipase

Share to Lipoproteins

Share to Plasma

Share to Proteoglycans

Source

Open in PubMed Open full text

Identifiers

PMID: 16200205
DOI: 10.1172/JCI26712
PMCID: PMC1236705

Genes

APOA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Give me A5 for lipoprotein hydrolysis!PMID 16200205Read ↗

APOA5 and triglyceride metabolism, lesson from human APOA5 deficiencySemantic proximity Read ↗

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients.Semantic proximity Read ↗

The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research.Semantic proximity Read ↗

Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment.Semantic proximity Read ↗

Update on APOA5 Genetics: Toward a Better Understanding of Its Physiological Impact.Semantic proximity Read ↗

Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.Semantic proximity Read ↗

Apolipoprotein A5 and triglyceridemia. Focus on the effects of the common variantsSemantic proximity Read ↗

Apolipoprotein A5 in health and disease.Semantic proximity Read ↗

Rare APOA5 mutations--clinical consequences, metabolic and functional effects: an ENID review.Semantic proximity Read ↗

The pathogenic mutations of APOA5 in Chinese patients with hyperlipidemic acute pancreatitisSemantic proximity Read ↗

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.Semantic proximity Read ↗

Mutations of the apolipoprotein A5 gene with inherited hypertriglyceridaemia: review of the current literature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.