Article
Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei.
Molecular microbiology - 1 Apr 2005
Stevens Mark P, Stevens Joanne M, Jeng Robert L, Taylor Lowrie A, Wood Michael W, Hawes Pippa, Monaghan Paul, Welch Matthew D, Galyov Edouard E
Abstract excerpt
Burkholderia pseudomallei is a Gram-negative facultative intracellular pathogen that enters and escapes from eukaryotic cells using the power of actin polymerization. We have identified a bacterial protein (BimA) that is required for the ability of B. pseudomallei to induce the formation of actin tails. BimA contains proline-rich motifs and WH2-like domains and shares limited homology at the C-terminus with the...
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