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Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand.

Scientific reports - 23 Oct 2024

Cagape Charlene Mae Salao, Seng Rathanin, Saiprom Natnaree, Tandhavanant Sarunporn, Chewapreecha Claire, Boonyuen Usa, West T Eoin, Chantratita Narisara

Abstract excerpt

Melioidosis is a life-threatening tropical disease caused by an intracellular gram-negative bacterium Burkholderia pseudomallei. B. pseudomallei polymerizes the host cell actin through autotransporters, BimA, and BimC, to facilitate intracellular motility. Two variations of BimA in B. pseudomallei have been reported previously: BimABp and BimA B. mallei-like (BimABm). However, little is known about genetic...

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PMID: 39443499
DOI: 10.1038/s41598-024-74922-3
PMCID: PMC11499645

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