Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

Abstract excerpt

Recombinant subunits of the transcription factor NF-kappa B, p50 and p65, were analyzed both for binding to various kappa B motifs and in vitro activation. The subunits preferentially form a heterodimer that activates transcription. Although p50 and p65 bind DNA individually as homodimers and are structurally related, their activation mechanisms are distinct. p65 activates transcription by its unique...

Topics

• Base Sequence
• DNA
• Gene Expression Regulation
• HeLa Cells
• Humans
• Molecular Sequence Data
• Mutation
• NF-kappa B
• NF-kappa B p50 Subunit
• Protein Conformation
• Protein Precursors
• Protein-Tyrosine Kinases