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Article

Generation and Activation of Multiple Dimeric Transcription Factors within the NF-κB Signaling System

25 Feb 2008

Abstract excerpt

The NF-kappaB signaling pathway regulates the activity of multiple dimeric transcription factors that are generated from five distinct monomers. The availabilities of specific dimers are regulated during cell differentiation and organ development and determine the cell's responsiveness to inflammatory or developmental signals. An altered dimer distribution is a hallmark of many chronic diseases. Here, we reveal...

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PMID: 18299388
DOI: 10.1128/mcb.01469-07

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