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Nuclear Factor-Kappa B: From Clone to Clinic

1 Nov 2007

Abstract excerpt

Nuclear transcription factor kappaB (NF-kappaB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the kappa immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-kappaB translocates to the nucleus where it upregulates the...

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PMID: 18045141
DOI: 10.2174/156652407782564363

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