NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

Abstract excerpt

PURPOSE OF REVIEW: To discuss recent advances in our understanding of the diverse roles of NF-κB/Rel family members in HIV-1 latency. RECENT FINDINGS: Various NF-κB/Rel family members can reinforce maintenance of HIV-1 latency. For example, p50 recruits histone deacetylase 1 to the HIV-1 long terminal repeat promoting chromatin condensation and reduced RNA Pol II recruitment. Low-level NF-κB activation during...

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