Article
Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.
The Journal of biological chemistry - 23 Oct 1998
Korfhagen T R, Sheftelyevich V, Burhans M S, Bruno M D, Ross G F, Wert S E, Stahlman M T, Jobe A H, Ikegami M, Whitsett J A, Fisher J H
Abstract excerpt
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (+/-) and SP-D (...
Topics
- Animals
- Female
- Gene Expression
- Genotype
- Glycoproteins
- Heterozygote
- Homeostasis
- Homozygote
- Lipidoses
- Male
- Mice
- Mice, Transgenic
- Phosphatidylcholines
- Proteolipids
- Pulmonary Alveoli
- Pulmonary Surfactant-Associated Protein A