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Article

Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.

Molecular and cellular biology - 1 Feb 2004

Moser Markus, Li Yong, Vaupel Kristina, Kretzschmar Doris, Kluge Reinhart, Glynn Paul, Buettner Reinhard

Abstract excerpt

Age-dependent neurodegeneration resulting from widespread apoptosis of neurons and glia characterize the Drosophila Swiss Cheese (SWS) mutant. Neuropathy target esterase (NTE), the vertebrate homologue of SWS, reacts with organophosphates which initiate a syndrome of axonal degeneration. NTE is expressed in neurons and a variety of nonneuronal cell types in adults and fetal mice. To investigate the physiological...

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Identifiers

PMID: 14749382
DOI: 10.1128/MCB.24.4.1667-1679.2004
PMCID: PMC344166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.PMID 14749382Read ↗

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.Semantic proximity Read ↗

Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.Semantic proximity Read ↗

Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolismSemantic proximity Read ↗

Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.Semantic proximity Read ↗

NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.Semantic proximity Read ↗

Neuropathy target esterase: An essential enzyme for neural development and axonal maintenanceSemantic proximity Read ↗

Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Semantic proximity Read ↗

The cyclic nucleotide binding sites of Swiss-Cheese, the <i>Drosophila</i> orthologue of human PNPLA6, are required for its catalytic functionSemantic proximity Read ↗

EEFSEC deficiency underlies a human selenopathy with primary neurodevelopmental origins via midbrain-hindbrain hypoplasia.Semantic proximity Read ↗

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesisSemantic proximity Read ↗

Neuropathy Target Esterase Is Required for Adult Vertebrate Axon MaintenanceSemantic proximity Read ↗

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.Semantic proximity Read ↗

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