Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.

doi:10.1128/MCB.24.4.1667-1679.2004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.

Molecular and cellular biology - 1 Feb 2004

Moser Markus, Li Yong, Vaupel Kristina, Kretzschmar Doris, Kluge Reinhart, Glynn Paul, Buettner Reinhard

Abstract excerpt

Age-dependent neurodegeneration resulting from widespread apoptosis of neurons and glia characterize the Drosophila Swiss Cheese (SWS) mutant. Neuropathy target esterase (NTE), the vertebrate homologue of SWS, reacts with organophosphates which initiate a syndrome of axonal degeneration. NTE is expressed in neurons and a variety of nonneuronal cell types in adults and fetal mice. To investigate the physiological...

Topics

Alleles
Animals
Apoptosis
Carboxylic Ester Hydrolases
Cell Differentiation
Cell Division
Cells, Cultured
Embryo Loss
Embryo, Mammalian
Gene Deletion
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Neovascularization, Physiologic

Placenta

Placentation

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 14749382
DOI: 10.1128/MCB.24.4.1667-1679.2004
PMCID: PMC344166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.PMID 14749382Read ↗

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.Semantic proximity Read ↗

Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.Semantic proximity Read ↗

Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolismSemantic proximity Read ↗

Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.Semantic proximity Read ↗

NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.Semantic proximity Read ↗

Neuropathy target esterase: An essential enzyme for neural development and axonal maintenanceSemantic proximity Read ↗

Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Semantic proximity Read ↗

The cyclic nucleotide binding sites of Swiss-Cheese, the <i>Drosophila</i> orthologue of human PNPLA6, are required for its catalytic functionSemantic proximity Read ↗

EEFSEC deficiency underlies a human selenopathy with primary neurodevelopmental origins via midbrain-hindbrain hypoplasia.Semantic proximity Read ↗

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesisSemantic proximity Read ↗

Neuropathy Target Esterase Is Required for Adult Vertebrate Axon MaintenanceSemantic proximity Read ↗

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.