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Article

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2005

Dalle Bruno, Rubin Joel E, Alkan Ozan, Sukonnik Tanya, Pasceri Peter, Yao Shuyuan, Pawliuk Rob, Leboulch Philippe, Ellis James

Abstract excerpt

beta-Globin transgenes regulated by the locus control region (LCR) are dominantly silenced by linked bacterial reporter genes in transgenic mice. Enhanced green fluorescent protein (eGFP) from jellyfish is an alternative reporter used in retrovirus vectors to transfer LCRbeta-globin genes into bone marrow. We show here that the eGFP coding sequence silences LCRbeta-globin in transgenic mice, but the PGK promoter...

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Identifiers

PMID: 15771961
DOI: 10.1016/j.ymthe.2004.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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