Virally targeted therapies for EBV-associated malignancies.

doi:10.1038/sj.onc.1206548

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Article

Virally targeted therapies for EBV-associated malignancies.

Oncogene - 11 Aug 2003

Israel Bruce F, Kenney Shannon C

Abstract excerpt

In Epstein-Barr virus (EBV)-positive lymphomas, the presence of the EBV genome in virtually all tumor cells, but very few normal cells, suggests that novel, EBV-targeted therapies could be used to treat these malignancies. In this paper, we review a variety of different approaches currently under development that specifically target EBV-infected cells for destruction. EBV-based strategies for treating cancer...

Topics

Antigens
Chromatin
DNA Methylation
Ganciclovir
Gene Transfer Techniques
Genes, Viral
Herpesvirus 4, Human
Humans
Models, Biological
Neoplasms
Phenotype
Tumor Cells, Cultured
Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 12910249
DOI: 10.1038/sj.onc.1206548

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