Article
Augmented latent membrane protein 1 expression from Epstein-Barr virus episomes with minimal terminal repeats.
Journal of virology - 1 Mar 2010
Repic Allison M, Shi Mingxia, Scott Rona S, Sixbey John W
Abstract excerpt
The major oncogene of the Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1), can be expressed from either of two promoters, ED-L1 or L1-TR, producing mRNAs of 2.8 kb or 3.5 kb, respectively. L1-TR, active in nasopharyngeal carcinoma and Hodgkin's lymphoma, is located within the first of a highly variable reiteration of terminal repeat (TR) sequences that are joined by random recombination upon...
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