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Article

Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma.

International journal of cancer - 1 Nov 2008

Dittmer Dirk P, Hilscher Chelsey J, Gulley Margaret L, Yang Eric V, Chen Min, Glaser Ronald

Abstract excerpt

Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how this viral episome is lost. Episome loss occurs naturally in nasopharyngeal carcinoma (NPC) upon explantation into culture. Using whole-genome profiling, we found evidence for 2 different pathways of episome loss: (i) rapid loss of the entire episome or (ii) successive...

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Share to Cell Line, Tumor
Share to DNA, Viral
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Nasopharyngeal Neoplasms

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Share to Recombination, Genetic

Source

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Identifiers

PMID: 18688856
DOI: 10.1002/ijc.23685
PMCID: PMC2866115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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