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Article

Role of etheno DNA adducts in carcinogenesis induced by vinyl chloride in rats.

IARC scientific publications - 1 Jan 1999

Barbin A

Abstract excerpt

Vinyl chloride, a hepatocarcinogen in humans and rodents, can form promutagenic etheno bases in DNA after metabolic activation. The formation of 1,N6-ethenoadenine (epsilon A) and 3,N4-ethenocytosine (epsilon C) was measured in adult Sprague-Dawley rats by immunoaffinity purification and 32P-postlabelling. A highly variable background was found in all tissues from untreated animals: the mean molar ratios of...

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PMID: 10626230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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