Article
1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells.
Biochemistry - 3 Sept 1996
Pandya G A, Moriya M
Abstract excerpt
1,N6-Ethenodeoxyadenosine (epsilon dA) is one of four exocyclic DNA adducts produced by chloroethylene oxide and chloroacetaldehyde, reactive metabolites of vinyl chloride, a human carcinogen. epsilon dA has also been detected in DNA of the liver of humans and untreated animals, suggesting its fo...
Topics
- Acetaldehyde
- Animals
- Base Sequence
- Cell Line
- Chromatography, High Pressure Liquid
- Cloning, Molecular
- DNA Adducts
- DNA, Single-Stranded
- Deoxyadenosines
- Deoxycytidine
- Escherichia coli
- Ethylene Oxide
- Humans
- Molecular Sequence Data
- Mutagens
- Mutation
- Nucleic Acid Conformation
- Plasmids