Article
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Endocrine reviews - 1 Oct 2001
Weinstein L S, Yu S, Warner D R, Liu J
Abstract excerpt
The heterotrimeric G protein G(s) couples hormone receptors (as well as other receptors) to the effector enzyme adenylyl cyclase and is therefore required for hormone-stimulated intracellular cAMP generation. Receptors activate G(s) by promoting exchange of GTP for GDP on the G(s) alpha-subunit (G(s)alpha) while an intrinsic GTPase activity of G(s)alpha that hydrolyzes bound GTP to GDP leads to deactivation....
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