Article
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.
Nature medicine - 1 Nov 2013
Regard Jean B, Malhotra Deepti, Gvozdenovic-Jeremic Jelena, Josey Michelle, Chen Min, Weinstein Lee S, Lu Jianming, Shore Eileen M, Kaplan Frederick S, Yang Yingzi
Abstract excerpt
Heterotopic ossification, the pathologic formation of extraskeletal bone, occurs as a common complication of trauma or in genetic disorders and can be disabling and lethal. However, the underlying molecular mechanisms are largely unknown. Here we demonstrate that Gαs restricts bone formation to the skeleton by inhibiting Hedgehog signaling in mesenchymal progenitor cells. In progressive osseous heteroplasia, a...
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