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Article

Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc.

The Journal of biological chemistry - 19 Sept 2003

Coddou Claudio, Morales Bernardo, González Jorge, Grauso Marta, Gordillo Felipe, Bull Paulina, Rassendren Francois, Huidobro-Toro J Pablo

Abstract excerpt

To elucidate the role of extracellular histidines in the modulation of the rat P2X4 receptor by trace metals, we generated single, double, and triple histidine mutants for residues 140, 241, and 286, replacing them with alanines. cDNAs for the wild-type and receptor mutants were expressed in Xenopus laevis oocytes and in human embryonic kidney 293 cells and examined by the two electrode and patch clamp...

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Identifiers

PMID: 12819199
DOI: 10.1074/jbc.M305177200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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