Article
The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis.
Hepatology (Baltimore, Md.) - 1 May 2001
Lara-Pezzi E, Serrador J M, Montoya M C, Zamora D, Yáñez-Mó M, Carretero M, Furthmayr H, Sánchez-Madrid F, López-Cabrera M
Abstract excerpt
The hepatitis B virus X protein (HBx) of the hepatitis B virus (HBV) has been involved in the development of hepatocellular carcinoma (HCC). However, its possible contribution to the metastatic spreading of liver tumors has not been explored so far. We report here the ability of HBx to enhance cell motility, both alone and in synergy with growth factors, and to induce a migratory phenotype in transformed cells....
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