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Article

Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.

Aging - 1 Apr 2011

Zhebrun Daria, Kudryashova Yulia, Babenko Alina, Maslyansky Alexei, Kunitskaya Natalya, Popcova Daria, Klushina Alexandra, Grineva Elena, Kostareva Anna, Shlyakhto Evgeny

Abstract excerpt

The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) is an important negative regulator of signal transduction through the T-cell receptors (TCR). Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG)...

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Identifiers

PMID: 21467606
DOI: 10.18632/aging.100305
PMCID: PMC3117451

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.PMID 21467606Read ↗

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Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.Semantic proximity Read ↗

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