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Article

A polymorphism of the bactericidal/permeability increasing protein (BPI) gene is associated with Crohn's disease.

Journal of clinical gastroenterology - 1 Apr 2005

Klein Wolfram, Tromm Andreas, Folwaczny Christian, Hagedorn Michaela, Duerig Natascha, Epplen Joerg, Schmiegel Wolff, Griga Thomas

Abstract excerpt

BACKGROUND: The bactericidal/permeability increasing protein (BPI) is involved in the elimination of gram-negative bacteria. A functionally relevant single nucleotide polymorphism of the BPI gene causes an amino acid exchange (Glu216Lys). STUDY: To evaluate whether this single nucleotide polymorphism contributes to the predisposition to inflammatory bowel disease, we compared the allele frequencies of 265...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15758620
DOI: 10.1097/01.mcg.0000155127.20290.07

Genes

BPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A polymorphism of the bactericidal/permeability increasing protein (BPI) gene is associated with Crohn's disease.PMID 15758620Read ↗

Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease.Semantic proximity Read ↗

Bactericidal/permeability increasing protein gene polymorphism and inflammatory bowel diseases: meta-analysis of five case-control studies.Semantic proximity Read ↗

Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population.Semantic proximity Read ↗

A645G (Lys216Glu) polymorphism of the bactericidal/permeability-increasing protein gene in periodontal disease.Semantic proximity Read ↗

A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide.Semantic proximity Read ↗

Association study of Wegener granulomatosis and the functionally relevant A645G polymorphism in the bactericidal/permeability increasing protein (BPI) gene.Semantic proximity Read ↗

Association between polymorphisms in exons 4 and 10 of the BPI gene and immune indices in Sutai pigs.Semantic proximity Read ↗

Genetic variation in exon 10 of the BPI gene is associated with Escherichia coli F18 susceptibility in Sutai piglets.Semantic proximity Read ↗

Screening of Pig (Sus scrofa) Bactericidal Permeability-Increasing Protein (BPI) Gene as Marker for Disease Resistance.Semantic proximity Read ↗

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?Semantic proximity Read ↗

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?Semantic proximity Read ↗

Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.Semantic proximity Read ↗

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