Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.

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Article

Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.

European journal of medical research - 27 Mar 2003

Debler J, Schiemann U, Seybold U, Mussack T, Landauer N, Ladurner R, Gross M

Abstract excerpt

BACKGROUND: 70 kDa Heat shock proteins are involved in mucosal protecting reactions in the gut of patients with inflammatory bowel disease. Recently, a single nucleotide polymorphism (PstI, nucleotide 1267) was associated with intestinal perforations and formation of abscesses and fistulas in Japanese patients with Crohn's disease. Our purpose was to evaluate this phenomenon in Caucasian patients with Crohn's...

Topics

Adolescent
Adult
Aged
Child
Crohn Disease
Female
Gene Frequency
Genotype
HSP70 Heat-Shock Proteins
Homozygote
Humans
Male
Middle Aged
Polymorphism, Genetic
Severity of Illness Index

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Open in PubMed

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PMID: 12730033

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