Article
Analysis of two chondroitin sulfate utilization mutants of Bacteroides thetaiotaomicron that differ in their abilities to compete with the wild type in the gastrointestinal tracts of germfree mice.
Applied and environmental microbiology - 1 Mar 1992
Hwa V, Salyers A A
Abstract excerpt
Previously, we isolated two mutants of Bacteroides thetaiotaomicron that were unable to grow on the mucopolysaccharide chondroitin sulfate (CS). One of these mutants (46-1) was outcompeted by the wild type in the intestinal tracts of germfree mice, whereas the other mutant (46-4) competed equally with the wild type. In the present article, we report a detailed characterization of these two mutants. Assays of...
Topics
- Animals
- Bacteroides
- Carbohydrate Sequence
- Chondroitin Sulfates
- Digestive System
- Electrophoresis, Gel, Two-Dimensional
- Germ-Free Life
- Heparin
- Mice
- Molecular Sequence Data