Article
Use of suppressor analysis to find genes involved in the colonization deficiency of a Bacteroides thetaiotaomicron mutant unable to grow on the host-derived mucopolysaccharides chondroitin sulfate and heparin.
Applied and environmental microbiology - 1 Feb 1995
Cheng Q, Salyers A A
Abstract excerpt
Bacteroides thetaiotaomicron, one of the numerically predominant species of human colonic bacteria, can ferment two types of host-derived mucopolysaccharides, chondroitin sulfate (CS) and heparin (HP). Originally, the pathways for utilization of CS and HP appeared to be completely independent of each other, but we have recently identified a gene, chuR, that links the two utilization systems. chuR is probably a...
Topics
- Bacterial Proteins
- Bacteroides
- Chondroitin Sulfates
- Colon
- DNA, Bacterial
- Fermentation
- Genes, Bacterial
- Genes, Suppressor
- Heparin
- Humans
- Mutagenesis, Insertional