Article
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017
Cartmell Alan, Lowe Elisabeth C, Baslé Arnaud, Firbank Susan J, Ndeh Didier A, Murray Heath, Terrapon Nicolas, Lombard Vincent, Henrissat Bernard, Turnbull Jeremy E, Czjzek Mirjam, Gilbert Harry J, Bolam David N
Abstract excerpt
The human microbiota, which plays an important role in health and disease, uses complex carbohydrates as a major source of nutrients. Utilization hierarchy indicates that the host glycosaminoglycans heparin (Hep) and heparan sulfate (HS) are high-priority carbohydrates for Bacteroides thetaiotaomicron, a prominent member of the human microbiota. The sulfation patterns of these glycosaminoglycans are highly...
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